The Lewis and Clark Expedition (1804-1806), headed by Meriwether Lewis and William Clark, was the first American overland expedition to the Pacific coast and back.

Earlier European exploration to the Pacific coast
In 1804, the Louisiana Purchase sparked interest in expansion to the west coast. A few weeks after the purchase, President Thomas Jefferson, an advocate of western expansion, had the Congress appropriate $2,500 for an expedition. In a message to Congress, Jefferson wrote

Louisiana Purchase and a western expedition
See also: Timeline of the Lewis and Clark Expedition
"Left Pittsburgh this day at 11 o'clock with a party of 11 hands 7 of which are soldiers, a pilot and three young men on trial they having proposed to go with me throughout the voyage." they bought from the Native Americans, plus one that they stole in "retaliation" for a previous theft. Less than a month after leaving Fort Clatsop, they abandoned their canoes because portaging around all the falls proved terribly difficult.
On July 3, after crossing the Continental Divide, the Corps split into two teams so Lewis could explore the Marias River. Lewis' group of four met some Blackfeet Indians. Their meeting was cordial, but during the night, the Blackfeet tried to steal their weapons. In the struggle, two Indians were killed, the only native deaths attributable to the expedition. The group of four: Lewis, Drouillard, and the Field brothers, fled over 100 miles (160 km) in a day before they camped again. Clark, meanwhile, had entered Crow territory. The Crow tribe were known as horse thieves. At night, half of Clark's horses were gone, but not a single Crow was seen. Lewis and Clark stayed separated until they reached the confluence of the Yellowstone and Missouri Rivers on August 11. Clark's team had floated down the rivers in bull boats. While reuniting, one of Clark's hunters, Pierre Cruzatte, blind in one eye and nearsighted in the other, mistook Lewis for an elk and fired, injuring Lewis in the thigh. From there, the groups were reunited and able to quickly return home by the Missouri River. They reached St. Louis on September 23, 1806.
The Corps of Discovery returned with important information about the new United States territory and the people who lived in it, as well as its rivers and mountains, plants and animals. The expedition made a major contribution to mapping the North American continent.

Reaction of the Spanish

The U.S. gained an extensive knowledge of the geography of the American West in the form of maps of major rivers and mountain ranges
Observed and described 178 plants and 122 species and subspecies of animals (see List of species described by the Lewis and Clark Expedition)
Encouraged Euro-American fur trade in the West
Opened Euro-American diplomatic relations with the Indians
Established a precedent for Army exploration of the West
Strengthened the U.S. claim to Oregon Territory
Focused U.S. and media attention on the West
Produced a large body of literature about the West (the Lewis and Clark diaries) Achievements

• "Seaman", Lewis' black Newfoundland dog.

Captain Meriwether Lewis — private secretary to President Thomas Jefferson and leader of the Expedition.
Lieutenant William Clark — shared command of the Expedition, although technically second in command.
York — Clark's enslaved black manservant.
Sergeant Charles Floyd — the Expedition's quartermaster; died early in the trip. He was the one person who died during the Expedition.
Sergeant Patrick Gass — chief carpenter, promoted to Sergeant after Floyd's death.
Sergeant John Ordway — responsible for issuing provisions, appointing guard duties, and keeping records for the Expedition.
Sergeant Nathaniel Hale Pryor — leader of the 1st Squad; he presided over the court martial of privates John Collins and Hugh Hall.
Corporal Richard Warfington — conducted the return party to St. Louis in 1805.
Private John Boley — disciplined at Camp Dubois and was assigned to the return party.
Private William E. Bratton — served as hunter and blacksmith.
Private John Collins — had frequent disciplinary problems; he was court-martialed for stealing whiskey which he had been assigned to guard.
Private John Colter — charged with mutiny early in the trip, he later proved useful as a hunter; he earned his fame after the journey.
Private Pierre Cruzatte — a one-eyed French fiddle-player and a skilled boatman.
Private John Dame
Private Joseph Field — a woodsman and skilled hunter, brother of Reubin.
Private Reubin Field — a woodsman and skilled hunter, brother of Joseph.
Private Robert Frazer — kept a journal that was never published.
Private George Gibson — a fiddle-player and a good hunter; he served as an interpreter (probably via sign language).
Private Silas Goodrich — the main fisherman of the expedition.
Private Hugh Hall — court-martialed with John Collins for stealing whiskey.
Private Thomas Proctor Howard — court-martialed for setting a "pernicious example" to the Indians by showing them that the wall at Fort Mandan was easily scaled.
Private François Labiche — French fur trader who served as an interpreter and boatman.
Private Hugh McNeal — the first white explorer to stand astride the headwaters of the Missouri River on the Continental Divide.
Private John Newman — court-martialed and confined for "having uttered repeated expressions of a highly criminal and mutinous nature."
Private John Potts — German immigrant and a miller.
Private Moses B. Reed — attempted to desert in August 1804; convicted of desertion and expelled from the party.
Private John Robertson — member of the Corps for a very short time.
Private George Shannon — was lost twice during the expedition, once for sixteen days. Youngest member of expedition at 19.
Private John Shields — blacksmith, gunsmith, and a skilled carpenter; with John Colter, he was court-martialed for mutiny.
Private John B. Thompson — may have had some experience as a surveyor.
Private Howard Tunn — hunter and navigator.
Private Ebenezer Tuttle — may have been the man sent back on June 12, 1804; otherwise, he was with the return party from Fort Mandan in 1805.
Private Peter M. Weiser — had some minor disciplinary problems at River Dubois; he was made a permanent member of the party.
Private William Werner — convicted of being absent without leave at St. Charles, Missouri, at the start of the expedition.
Private Isaac White — may have been the man sent back on June 12, 1804; otherwise, he was with the return party from Fort Mandan in 1805.
Private Joseph Whitehouse — often acted as a tailor for the other men; he kept a journal which extended the Expedition narrative by almost five months.
Private Alexander Hamilton Willard — blacksmith; assisted John Shields. He was convicted on July 12, 1804, of sleeping while on sentry duty and given one hundred lashes.
Private Richard Windsor — often assigned duty as a hunter.
Interpreter Toussaint Charbonneau — Sacagawea's husband; served as a translator and often as a cook.
Interpreter Sacagawea — Charbonneau's wife; translated Shoshone to Hidatsa for Charbonneau and was a valued member of the expedition.
Jean Baptiste Charbonneau — Charbonneau and Sacagawea's son, born February 11, 1805; his presence helped dispel any notion that the expedition was a war party, smoothing the way in Indian lands.
Interpreter George Drouillard — skilled with Indian sign language; the best hunter on the expedition.
"Seaman", Lewis' black Newfoundland dog. Expedition members

The episode "Margical History Tour" of the American TV series The Simpsons contains a fictional retelling of the Lewis and Clark expedition.
The rescue ship in Science fiction/Horror film Event Horizon is named the Lewis and Clark.
The Comedy Almost Heroes starring Chris Farley and Matthew Perry features a fictional party attempting to best Lewis and Clark in their journey to the Pacific Ocean.
Often parodied in the comic strip The Far Side by Gary Larson.
The Histeria! episode "Great Heroes of France" had one segment called "Lewis and Clark", which had Clark's animation style and voice based on the Superman: The Animated Series version of Clark Kent. The sketch's name spoofed the TV-series Lois & Clark: The New Adventures of Superman which in turn spoofed the original naming of Lewis and Clark. In addition to this, Clark's voice was made to resemble Dean Martin, to match Lewis' portrayal as Jerry Lewis.
A song titled "Lewis and Clark" is found on The Mystery CD by Tommy Emmanuel.
In 1955 the movie The Far Horizons was released, starring Fred MacMurray as Meriwether Lewis, Charlton Heston as William Clark, Donna Reed as Sacajawea, and Barbara Hale as Julia Hancock. The movie perpetuates the myth of a romantic relationship between Sacajawea and William Clark. The end has Sacajawea and Julia Hancock realizing they are both in love with the same man. Realizing she can never fit into white society, Sacajawea goes back to her people. The movie is based on Della Gould Emmons' novel "Sacajawea of the Shoshones" (Portland OR : Binfords and Mort, 1943).
In the 1988 movie National Lampoon's European Vacation, the Griswalds won the game show when, while deciding how to answer the question about the "Lewis and what Expedition", the wife addressed her husband by his first name, "Clark?"
The lead character in Robert Heinlein's space exploration classic science fiction novel Time for the Stars was posted on a ship called "The Lewis and Clark", or "Elsie" to the crew.
In Harry Turtledove's World War and Colonization Series, the American Space Station which later turned into Earth's first Spaceship was named "The Lewis and Clark."
Since the late 1990s, the Pacific Northwest regional air carrier Horizon Air, has been using radio advertisements that feature Meriweather Lewis (portrayed by actor Patrick Warburton) and William Clark (actor Richard Kind) as modern day travelers. The advertisements juxtapose the hardships faced by the Expedition as compared to the relative comfort and convenience of air travel. Lewis is portrayed as the calm leader, while Clark is often trying to upstage his partner and refers to "Clark and Lewis Expedition" on several occasions.
In the animated show Gary & Mike, Gary tries to follow the route of the Lewis and Clark Expedition by car, with continual interruptions and side-tracks by his friend, Mike. In popular culture

Timeline of the Lewis and Clark Expedition
History of the United States
USS Lewis and Clark and USNS Lewis and Clark
Jefferson National Expansion Memorial Further reading

Lewis and Clark Among the Indians, James P. Ronda, 1984 - ISBN 0-8032-3870-3
Undaunted Courage, Stephen Ambrose, 1997 - ISBN 0-684-82697-6
National Geographic Guide to the Lewis & Clark Trail, Thomas Schmidt, 2002 - ISBN 0-7922-6471-1
The Lewis and Clark Journals: An American Epic of Discovery (abridged), edited by Gary E. Moulton, 2003 - ISBN 0-8032-2950-X
The Journals of the Lewis and Clark Expedition, 13-Volume Set, edited by Gary E. Moulton, 2002 - ISBN 0-8032-2948-8
The complete text of the Lewis and Clark Journals online, University of Nebraska-Lincoln (in progress)
In Search of York: The Slave Who Went to the Pacific With Lewis and Clark, Robert B. Betts, 2002 - ISBN 0-87081-714-0
Online text of the Expedition's Journal at Project Gutenberg
Lewis & Clark: The Journey of the Corps of Discovery, Ken Burns, 1997 - ISBN 0-679-45450-0
Lewis and Clark: across the divide, Carolyn Gilman, 2003. Washington, D.C.: Smithsonian Books. ISBN 1588340996